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Renal clearance of cotinine is much less compared to glomerular filtration amount (Benowitz et al. 2008b). Considering the fact that cotinine just isn't appreciably protein bound, this indicates considerable tubular reabsorption. Renal clearance of cotinine is often Improved by approximately fifty% with Severe urinary acidification. Cotinine excretion is fewer affected https://mrdistro.com/

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