The scientists discovered the pocket opens for brief periods of time, permitting the modified cannabinoid compound to bind, thus minimizing tolerance. Over the past couple many years, the quantity of THC in cannabis has steadily climbed; present day marijuana has thrice the concentration of THC compared to 25 yrs back. https://elliotbsiym.bloguetechno.com/the-basic-principles-of-euphoria-inducing-substances-70807425